Microsatellite Evolution: Testing the Ascertainment Bias Hypothesis
نویسندگان
چکیده
منابع مشابه
Genome-wide analysis of microsatellite polymorphism in chicken circumventing the ascertainment bias.
Studies of microsatellites evolution based on marker data almost inherently suffer from an ascertainment bias because there is selection for the most mutable and polymorphic loci during marker development. To circumvent this bias we took advantage of whole-genome shotgun sequence data from three unrelated chicken individuals that, when aligned to the genome reference sequence, give sequence inf...
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Microsatellite loci play an important role as markers for identification, disease gene mapping, and evolutionary studies. Mutation rate, which is of fundamental importance, can be obtained from interspecies comparisons, which, however, are subject to ascertainment bias. This bias arises, for example, when a locus is selected on the basis of its large allele size in one species (cognate species ...
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Microsatellite loci play an important role as markers for identi cation, disease gene mapping and evolutionary studies. Mutation rate, which is of fundamental importance, can be obtained from interspecies comparisons, which however are subject to ascertainment bias. This bias arises for example when a locus is selected based on its large allele size in one species (cognate species 1), in which ...
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ژورنال
عنوان ژورنال: Journal of Molecular Evolution
سال: 1998
ISSN: 0022-2844
DOI: 10.1007/pl00006301